|
KMID : 0356920180710010022
|
|
Korean Journal of Anesthesiology
2018 Volume.71 No. 1 p.22 ~ p.29
|
|
|
Optimal propofol dosage for i-gel® insertion in healthy paralyzed patients
|
|
Cho Sung-Ae
Sung Tae-Yun
Cho Choon-Kyu
Jee Young-Seok
Kang Po-Soon
|
|
|
Abstract
|
|
|
Background: Propofol is used for supraglottic airway device insertion, often with the i-gel. However, the propofol requirement for i-gel insertion has not been explored in paralyzed patients. This study was performed to explore hemodynamic changes and sedation level with different propofol doses in healthy paralyzed patients when the i-gel was inserted.
Methods: A total of 141 patients undergoing a urologic operation were randomly allocated to three groups depending on the propofol dose (1.5, 2, and 2.5 mg/kg; Groups P1.5, P2, and P2.5, respectively). After patients had been administered each propofol dose and rocuronium, the i-gel was inserted and changes in hemodynamic parameters and bispectral index were evaluated.
Results: Group P2 showed a lower incidence of complications (17%) such as hemodynamic instability and inadequate sedation than Group P1.5 (55.3%, P < 0.001) or Group P2.5 (40.4%, P = 0.012). The incidence and dose of additional propofol increased in Group P1.5 (51%, median [range]; 20 [0?50]) compared with those in the other groups (0%, 0 [0?0] in Group P2 and 8.5%, 0 [0?50] in Group P2.5, all P < 0.001), and the incidence and dose of additional ephedrine were significantly higher in Group P2.5 (31.9%; 0 [0?20]) than in Group P1.5 (10.6%, P = 0.012; 0 [0?5], P = 0.007, respectively).
Conclusions: For the stable maintenance of hemodynamic parameters and proper sedation level during i-gel insertion, 2 mg/kg propofol has an advantage over 1.5 mg/kg or 2.5 mg/kg propofol in healthy paralyzed patients.
|
|
|
KEYWORD
|
|
|
Hemodynamics, i-gel, Propofol, Rocuronium
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|
|